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Prep the Roast:
Preheat oven to 325°F (165°C).
Rub pork loin with salt, pepper, garlic powder, and onion powder.
Place in a roasting pan or Dutch oven.
Make the Coca-Cola Sauce:
In a bowl, mix Coca-Cola, ketchup, brown sugar, Worcestershire sauce, and vinegar.
Stir well until sugar dissolves.
Roast:
Pour the sauce over the pork loin.
Cover with foil or a lid and bake for 2.5 to 3 hours, basting every 30–45 minutes.
Uncover for the last 30 minutes to allow sauce to thicken and caramelize.
Serve:
Let rest 10–15 minutes before slicing.
Serve with extra sauce spooned over top.
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